Mitchell C Brenner Selected Research

3,4-dehydroproline

12/2004

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

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Mitchell C Brenner Research Topics

Disease

2	Hypoxia (Hypoxemia) 01/2020 - 12/2004
1	Iron Deficiencies 01/2020
1	Anemia 01/2020
1	Inflammation (Inflammations) 01/2020
1	Chronic Renal Insufficiency 01/2020
1	Osteosarcoma (Osteogenic Sarcoma) 05/2003
1	Autosomal Recessive Type VII Ehlers-Danlos Syndrome 05/2003
1	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 05/2003

Drug/Important Bio-Agent (IBA)

2	Transcription Factors (Transcription Factor)IBA 01/2020 - 12/2004
1	Prolyl-Hydroxylase InhibitorsIBA 01/2020
1	roxadustatIBA 01/2020
1	Erythropoietin FDA Link 01/2020
1	Hormones (Hormone)IBA 01/2020
1	IronIBA 01/2020
1	MetalsIBA 01/2020
1	Peptidoglycan (Murein)IBA 01/2020
1	Polysaccharides (Glycans)IBA 01/2020
1	Cytochromes b (Cytochrome b)IBA 01/2020
1	HepcidinsIBA 01/2020
1	Peptides (Polypeptides)IBA 12/2004
1	Azetidinecarboxylic AcidIBA 12/2004
1	Hypoxia-Inducible Factor-Proline DioxygenasesIBA 12/2004
1	leucyl-alanineIBA 12/2004
1	Proline (L-Proline)FDA Link 12/2004
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 12/2004
1	3,4-dehydroprolineIBA 12/2004
1	EnzymesIBA 05/2003
1	Messenger RNA (mRNA)IBA 05/2003
1	Collagen Type III (Type III Collagen)IBA 05/2003
1	Cycloheximide (Cicloheximide)IBA 05/2003
1	Peptide Hydrolases (Proteases)FDA Link 05/2003
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 05/2003
1	ProcollagenIBA 05/2003
1	Metalloproteases (Metalloproteinases)IBA 05/2003

Therapy/Procedure

1	Nephrectomy 01/2020